1152311-62-0 Tezacaftor

Proprjetajiet

Dehra bajda għal isfar solidu
Punt tat-togħlija: 61 0. 8 ± 55.0 grad
Densità 1.49 ± 0. 1 g / cm3
Temp tal-Ħażna. Aħżen fi -20 grad, maħżun taħt in-nitroġenu
Solubilità akbar minn jew daqs 21.8 mg / ml fid-DMSO; li ma jinħallx fl-EtOH; Akbar minn jew daqs 24.3 mg / ml f'H2O
PKA13.99 ± 0. 20

 

Applikazzjoni:

Tezacaftor huwa prinċipalment użat għat-trattament ta 'pazjenti ta' fibrożi ċistika adulta (CF) ta '12 -il sena 'l fuq li huma omożġiċi għall-mutazzjoni tal-ġene f508del jew għandhom mill-inqas mutazzjoni waħda fil-ġene tal-fattur ta' konduzzjoni transmembrane ċistika (CTFR), u għandhom in vitro klinika evidenza li turi sensittività għal dan il-prodott.

 

Sinonimi:

Tezacaftor

1152311-62-0

(R) -1- (2, 2- difluorobenzo [d] [1,3] dioxol -5-}} yl) -n - ({1- (2, {3- dihydroxypropyl) -6- Flu oro -2- (1- hydroxy -2- methylpropan -2- yl) -1 h-indol -5- yl) cyclopropaneCarboxamide

CyclopropaneCarboxamide, 1- (2, 2- difluoro -1, 3- benzodioxol {-5- yl) -n - [{1- [(2r) {10} }, 3- dihydroxyp ropyl] -6- fluoro -2- (2- hydroxy -1, {1- dimethylethyl) -1} h-indol -5- yl] - - -

CyclopropaneCarboxamide, 1- (2, 2- difluoro -1, {3- benzodioxol {-5- yl) -n - ({1- ((2r) {10} }, 3- dihydroxyp ropyl) -6- fluoro -2- (2- hydroxy -1, {1- dimethylethyl) -1} h-indol -5- yl) - -

1- (2, 2- difluoro -1, 3- benzodioxol {-5- y l) -n - (1- ((2r) -2, 3- dihydroxypropyl) {{{12} } fluoro -2- (2- hydroxy -1, 1- dimetilethyl) {-1 h-indol -5- yl) cyclopopaneCarboxamide

1- (2, 2- difluoro -1, 3- benzodioxol {-5- yl) -n - [{1- [(2r) {10} }, 3- dihydroxypropyl] {{12 }} fluoro -2- (1- hydroxy -2- methylPopan -2-} yl) indol -5- yl] cyclopropan -1- carboxamide

1- (2, 2- difluoro -1, 3- benzodioxol {-5- y L) -n - {1- [(2r) -2, 3- dihydroxypropyl] {{{12 }} Fluoro -2- (1- hydroxy -2- methylpran -2-}} yl) indol -5- yl} cyclopropan -1- carboxamide

C26H27F3N2O6

Tezacaftor

Komponent Symkevi Tezacaftor

Komponent Trikafta Tezacaftor

 

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